Xeomin is another Botulinum toxin A like Botox and Dysport with a very similar safety profile and effectiveness. Xeomin and Botox work the same way to paralyze muscles and smooth wrinkles. They share the identical active ingredient – botulinum toxin A. The difference is that Botox has an accompanying protein, but xeomin is naked.Botulinum toxin is a naturally occurring protein produced by the bacteria Clostridium botulinum. Botulinum toxin type A—the active ingredient in XEOMIN—is produced commercially from C. botulinum serotype A. XEOMIN is injected into muscles to decrease their activity. XEOMIN blocks the release of a chemical messenger—acetylcholine—that conveys the signal from nerve terminals and causes muscle fibers to contract. Not all terminals are affected by botulinum toxin, so the muscles can still contract, just less forcefully. This allows the muscles to contract more normally.